Simulation with HTSTsterilisation.fig

T: temperature (C); LR: Lethal rate; FTK: Sterilisation time calculated with the 1st order kinetics and Arrhenius concept. FTD : Sterilisation time calculated with the D- and Z- value concept.

The simulation calculates the required sterilisation time (min) to reach a given sterility criterion at different temperature. The calculations are based on the two common concepts: 1st order death rate (k) and its teperature dependance decribed by the activation energy, and the concept of decimal reduction time (D) and its temeprature dependance described by the Z-value. Tempertures in the range of 140 C are used in continuous sterilisation, while temperature of 121 C is used in autoclaving.
The same theory and models can be used also for pasteurisation (T 60-90 C).
For more information about the theory of sterilisation, see Fermentation Process Engineering, 2nd ed. (will be available on

For information about model equations and parameters: Open the SIMSPEC-file HTSTsterilisation.fig, available in the SimuPlot toolbox.

Updated 2015-12-22